Here are the result possibilities from e-tegrity's website:
There are three typical patterns:
1. Beta-3 integrin POSITIVE with an “in-phase” endometrium is a normal pattern of expression.
2. Beta-3 integrin NEGATIVE with an “out-of-phase” endometrium occurs in a patient with Luteal Phase Defect; following treatment the patient is advised to undergo a repeat biopsy to confirm diagnosis.
3. Beta-3 integrin NEGATIVE in a patient with a normal “in phase” endometrium is associated with unexplained infertility, minimal or mild endometriosis, or hydrosalpinx.
The E-tegrity test:
Identifies endometrial quality
Determines Beta-3 integrin presence
Provides a histologic evaluation of the endometrium
My results came back positive and in-phase!!!! Wahooo!!! I am so so so so happy!
So what I conclude from this is that my implantation failure was due to either abnormal embryos (all 8 of them) or more probable my crazy e2 levels during stims, which btw were IVF#1: 6867 IVF#2: 9029 IVF#3: 6045. During a natural cycle, e2 peaks at 200-600, so it would totally make sense that that high of an e2 level could definitely disrupt the uterine environment. So no more fresh transfers for me again, ever!
I also conclude that my inability to conceive naturally is most likely due to very weak sperm that are attacked by antisperm antibodies. Kerry developed ASAs from having a vasectomy.
Now I feel free to finally make a plan... though at this time, I have no clue what that is.
On a completely different note, I'm miserable. I got food poisoning last night. I had sour stomach all day Sun and by bed time, as I went to brush my teeth, I become violently ill. I dropped to the ground, was instantly drenched in sweat and was shaking uncontrollably. I drug myself to the toilet just in time as I knew something was going to explode, I just didn't know which end. I had bad diarrhea, sorry if that was TMI. When I leaned forward, I was about to throw up, so I had to lean back, but then I was slipping off the toilet because my legs were so sweaty. Kerry came in, held me up and put towels under my legs so I would stop sliding. My body was spasming really bad so I had no control over myself. My entire body tingled like it had fallen asleep, my wrists and hands painfully locked up. Kerry tried to straighten out my wrists and separate my fingers, but they wouldn't release, it was like a massive charlie horse from hell. Then my feet and face went numb and caused my speech to slur. I had to get to the ground, fast. Kerry insisted on wiping my butt as my hands were useless. He said, "now it's front to back right?", gotta love him! He helped me to the ground, covered me in towels and put a heater on me. He layed there on the bathroom floor with me for a half an hour massaging my hands trying to get them to release.
Anyone ever experience their wrists/hands locking up? It was so strange! Kerry thinks it was from the chemical that causes your stomach/intestines to convulse to get rid of the bad stuff.
I'm doing much better today, but feeling really weak, exhausted from no sleep and running a fever. I just have to say, do I not have an amazing husband or what! I teared up knowing that he will always take care of me and I know I can always count on him. I can't wait for him to help me through labor and delivery... someday... someday...
PS... thank you MLG for the sisterhood award, that was very sweet of you!